The main difference between a gate valve and a globe valve is their inner elements and flow characteristics. The globe valve offers the good regulating ability, whereas the gate valve is best operated in a fully open or closed position. The globe valve is a regulation valve, whereas the gate valve is an isolation valve.
Another key difference between them is the direction in which they can be installed. A globe valve can be installed in a single direction, whereas a gate valve can be installed in various directions.